Porting the Sisal functional language to distributed-memory multiprocessors

Parallel computing is becoming increasingly ubiquitous in recent years. The sizes of application problems continuously increase for solving real-world problems. Distributed-memory multiprocessors have been regarded as a viable architecture of scalable and economical design for building large scale parallel machines. While these parallel machines can provide computational capabilities, programming such large-scale machines is often very difficult due to many practical issues including parallelization, data distribution, workload distribution, and remote memory latency. This thesis proposes to solve the programmability and performance issues of distributed-memory machines using the Sisal functional language. The programs written in Sisal will be automatically parallelized, scheduled and run on distributed-memory multiprocessors with no programmer intervention. Specifically, the proposed approach consists of the following steps. Given a program written in Sisal, the front end Sisal compiler generates a directed acyclic graph(DAG) to expose parallelism in the program. The DAG is partitioned and scheduled based on loop parallelism. The scheduled DAG is then translated to C programs with machine specific parallel constructs. The parallel C programs are finally compiled by the target machine specific compilers to generate executables. A distributed-memory parallel machine, the 80-processor ETL EM-X, has been chosen to perform experiments. The entire procedure has been implemented on the EMX multiprocessor. Four problems are selected for experiments: bitonic sorting, search, dot-product and Fast Fourier Transform. Preliminary execution results indicate that automatic parallelization of the Sisal programs based on loop parallelism is effective. The speedup for these four problems is ranging from 17 to 60 on a 64-processor EM-X. Preliminary experimental results further indicate that programming distributed-memory multiprocessors using a functional language indeed frees the programmers from lowl-evel programming details while allowing them to focus on algorithmic performance improvement

Clerodendrum inerme

Previously, we found a patient with intractable motor tic disorder, a spectrum of Tourette syndrome (TS), responsive to the ground leaf juice of Clerodendrum inerme (CI). Here, we examined the effect of the ethanol extract of CI leaves (CI extract) on animal behaviors mimicking TS, hyperlocomotion, and sensorimotor gating deficit. The latter is also observed in schizophrenic patients and can be reflected by a disruption of prepulse inhibition of acoustic startle response (PPI) in animal models induced by methamphetamine and NMDA channel blockers (ketamine or MK-801), based on hyperdopaminergic and hypoglutamatergic hypotheses, respectively. CI extract (10–300 mg/kg, i.p.) dose-dependently inhibited hyperlocomotion induced by methamphetamine (2 mg/kg, i.p.) and PPI disruptions induced by methamphetamine, ketamine (30 mg/kg, i.p.), and MK-801 (0.3 mg/kg, i.p.) but did not affect spontaneous locomotor activity, rotarod performance, and grip force. These results suggest that CI extract can relieve hyperlocomotion and improve sensorimotor gating deficit, supporting the therapeutic potential of CI for TS and schizophrenia

RE-EXAMINING FACTORS INFLUENCING INFORMATION TECHNOLOGY ACCEPTANCE BY INDIVIDUAL PROFESSIONALS

This study proposed a comprehensive decomposed TPB model to understand the factors influencing the intentions of individual professionals to use information technology. A field survey was conducted to collect analysis data from physicians who have used Medline system, a kind of evidence-based medicine database, in Taiwan. After the research model was tested by the partial least square method with bootstrap estimate, we found that decomposed TPB provides effective prediction of physicians\u27 acceptance intention of the Medline system. Comparing to subjective norm and perceived behavioral control, attitudes towards using the IS provide better predictive power for behavioral intention. In addition, perceived usefulness and perceived ease of use have significant impact on attitude, respectively. Perceived ease of use has significant impact on perceived usefulness. The variance of subjective norm can be effectively explained by interpersonal influence. Personal innovativeness in IT not only directly influences perceived behavioral control, but also indirectly influences perceived behavioral control through self-efficacy. However, the facilitating conditions have no significant effect on perceived behavioral control. These findings not only provide insights for further research related to information technology acceptance by individual professionals, but also offer medical institutions practical suggestions

Clerodendrum inerme Leaf Extract Alleviates Animal Behaviors, Hyperlocomotion, and Prepulse Inhibition Disruptions, Mimicking Tourette Syndrome and Schizophrenia

Previously, we found a patient with intractable motor tic disorder, a spectrum of Tourette syndrome (TS), responsive to the ground leaf juice of Clerodendrum inerme (CI). Here, we examined the effect of the ethanol extract of CI leaves (CI extract) on animal behaviors mimicking TS, hyperlocomotion, and sensorimotor gating deficit. The latter is also observed in schizophrenic patients and can be reflected by a disruption of prepulse inhibition of acoustic startle response (PPI) in animal models induced by methamphetamine and NMDA channel blockers (ketamine or MK-801), based on hyperdopaminergic and hypoglutamatergic hypotheses, respectively. CI extract (10-300 mg/kg, i.p.) dose-dependently inhibited hyperlocomotion induced by methamphetamine (2 mg/kg, i.p.) and PPI disruptions induced by methamphetamine, ketamine (30 mg/kg, i.p.), and MK-801 (0.3 mg/kg, i.p.) but did not affect spontaneous locomotor activity, rotarod performance, and grip force. These results suggest that CI extract can relieve hyperlocomotion and improve sensorimotor gating deficit, supporting the therapeutic potential of CI for TS and schizophrenia

Correction: The Critical Role of Early Dengue Surveillance and Limitations of Clinical Reporting - Implications for Non-Endemic Countries.

[This corrects the article DOI: 10.1371/journal.pone.0160230.]

The impact of preoperative waiting time in Stage II–III gastric or gastroesophageal junction cancer: A population‐based cohort study

Abstract Background Gastrectomy remains the curative option in gastric cancer. However, the growing concern that preoperative waiting jeopardizes survival has not been fully addressed. The present population‐based cohort study aimed to clarify the impact of preoperative waiting time (PreWT). Methods We included patients with clinical Stage II–III gastric cancer who received curative surgery from 2008 to 2017 of Taiwan Cancer Registry. PreWT was defined as the time from endoscopic diagnosis to surgery. The prognostic impact on overall survival (OS) was evaluated with Cox and restricted cubic spline regressions. Results A total of 3059 patients with a median age of 68 years were evaluated. The median PreWT was 16 days (interquartile range, 11–24 days), and patients with a shorter PreWT were younger, had a more advanced disease and received adjuvant therapies. Despite a shorter OS occurring with prolonged PreWT (median OS by PreWT [days]: 7–13, 2.7 years; 14–20, 3.1 years; 21–27, 3.0 years; 28–34, 4.7 years; 35–31, 3.7 years; 42–48, 3.4 years; 49–118, 2.8 years; p = 0.029), the differences were not significant after adjustment. The Cox and restricted cubic spline regressions showed that prolonged PreWT was not a significant prognostic factor for OS (p = 0.719). Conclusions The population‐based study suggests that a PreWT of 49–118 days does not independently correlate with a poor prognosis in Stage II–III gastric cancer. The study provides rationale for a window period for preoperative therapies and patient optimization

Lycopodium casuarinoides Spring

原著和名: ヒモヅル科名: ヒカゲノカズラ科 = Lycopodiaceae採集地: 鹿児島県 屋久島 屋久町 安房林道 (大隅 屋久島 屋久町 安房林道)採集日: 1989/10/12採集者: 萩庭丈壽整理番号: JH016078国立科学博物館整理番号: TNS-VS-96607

Comparison between reported versus unreported indigenous laboratory confirmed dengue cases in surveillance, epidemiological characteristics and clinical symptoms, through the three epidemic stages in Kaohsiung City, during 2009–2010 epidemic of dengue/DHF.

<p>Comparison between reported versus unreported indigenous laboratory confirmed dengue cases in surveillance, epidemiological characteristics and clinical symptoms, through the three epidemic stages in Kaohsiung City, during 2009–2010 epidemic of dengue/DHF.</p